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This course is taught by several faculty within the Joint Program in Nuclear Medicine at RIRS and its teaching affiliates.
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Center for Advanced Medical Imaging Sciences
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Research Laboratory for Metastasis Imaging
About us
The Laboratory for metastasis imaging research focuses on hyperpolarized 13C magnetic resonance spectroscopic (MRS)imaging to diagnose and monitorthe early therapeutic efficacy.

Principle of Hyperpolarization
This physical phenomenon based on nuclear Overhausereffect (NOE) which was first proposed by Albert Overhauser in 1953. Hyperpolarization by Dynamic Nuclear polarization is based on the transfer of polarization from the electron spins of paramagnetic centers embedded in a glassy frozen solution to neighboring nuclear spins of 13C carbonthrough dipolar interaction, which make it possible to increase MR signal over 10,000 fold.

13C Metabolic Imaging
Metabolic imaging using hyperpolarized 13C MRS imaging quantitatively visualize cellular metabolism in the level of molecular and chemical process in living organisms without perturbing them. There are around 70 possible 13C enriched endogenous compounds available which are involved in cellular metabolism. For example, [1-13C] pyruvate ismostly investigated substrate to date which reflectsits central role in cellular metabolism. [1-13C] pyruvate exchangeslabel with endogenous substance lactate by lactate dehydrogenasewhich is highly expressed by cancer cells. Becausecancer cells have high rates of glucose consumption and lactate production,this characteristicfeatured can be used to diagnose cancer.
1. Development of hyperpolarized 13C magnetic resonance spectroscopic imaging techniques to evaluate earlier
    therapeutic efficacy inmetastasis model.
2. Development of spatially encoded metabolic information using hyperpolarized 13C MRS imaging in hepatocellular
    carcinoma model.
3. Development high resolution metabolic brain mapping in Alzheimer's disease mouse model.
Name Position Email address Phone number
Ho-Taek Song Associate Professor hotsong@yuhs.ac 2228-2370
Young-Suk Choi Research Assistant professor Young-suk42@yuhs.ac 2228-0848
Hyun-Jin Park PhD student ever49@yuhs.ac 2228-0848
Eun-Kyung Wang Researcher ekwang@yuhs.ac 2228-0848
Min-Jin Kim Researcher minjin0710@yuhs.ac 2228-0848
1. Shin TH, Choi JS, Yun S, Kim IS, Song HT, Kim Y, T₁ and T₂ dual-mode MRI contrast agent for enhancing accuracy by
    engineered nanomaterials. ACS Nano 2014 Apr 22; 8(4):3393-401
2. Lee YH, Kim S, Lim D, Suh JS, Song HT. Spectral parametric segmentation of contrast-enhanced dual-energy CT to
    detect bone metastasis: feasibility sensitivity study using whole-body bone scintigraphy. ActaRadiol.2014 Apr 8.
3. Ahn SJ, Koom WS, An CS, Lim JS, Lee SK, Suh JS, Song HT. Quantitative assessment of tumor responses after radiation
    therapy in a DLD-1 colon cancer mouse model using serial dynamic contrast-enhanced magnetic resonance imaging.
    Yonsei Med J. 2012 Nov 1;53(6):1147-53.
4. Ahn SJ, An CS, Koom WS, Song HT, Suh JS. Correlations of 3T DCE-MRI quantitative parameters with microvessel
    density in a human-colorectal-cancer xenograft mouse model. Korean J Radiol. 2011 Nov-Dec;12(6):722-30
5. Song HT, Jordan EK, Lewis BK, Gold E, Liu W, Frank JA. Quantitative T2* imaging of metastatic human breast cancer to
    brain in the nude rat at 3 T. NMR Biomed. 2011 Apr;24(3):325-34
6. Lee ES, Oh YT, Youn YS, Nam M, Park B, Yun J, Kim JH, Song HT, Oh KT. Binary mixing of micelles using Pluronics for a
    nano-sized drug delivery system. Colloids Surf B Biointerfaces. 2011 Jan 1;82(1):190-5
7. Lee YH, Andersen JB, Song HT, Judge AD, Seo D, Ishikawa T, Marquardt JU, Kitade M, Durkin ME, Raggi C, Woo HG,
    Conner EA, Avital I, Maclachlan I, Factor VM, Thorgeirsson SS. Definition of ubiquitination modulator COP1 as a novel
    therapeutic target in human hepatocellular carcinoma. Cancer Res. 2010 Nov 1;70(21):8264-9.
8. Choi JS, Lee JH, Shin TH, Song HT, Kim EY, Cheon J. Self-confirming "AND" logic nanoparticles for fault-free MRI. J Am
    Chem Soc. 2010 Aug 18;132(32):11015-7.
9. Song HT, Jordan EK, Lewis BK, Liu W, Ganjei J, Klaunberg B, Despres D, Palmieri D, Frank JA. Rat model of metastatic
    breast cancer monitored by MRI at 3 tesla and bioluminescence imaging with histological correlation. J Transl Med. 2009
    Oct 20;7(88)1186/1479-5876-7-88.
10. Lee JH, Huh YM, Jun YW, Seo JW, Jang JT, Song HT, Kim S, Cho EJ, Yoon HG, Suh JS, Cheon J. Artificially engineered
    magnetic nanoparticles for ultra-sensitive molecular imaging.Nat Med. 2007 Jan;13(1):95-9.
11. Song HT, Choi JS, Huh YM, Kim S, Jun YW, Suh JS, Cheon J. Surface modulation of magnetic nanocrystals in the
    development of highly efficient magnetic resonance probes for intracellular labeling. J Am Chem Soc. 2005 Jul 20;127
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